More than half of the 232 voluntary medication overdoses recorded in the last six years at the Paediatric Emergency Department of ULS Santa Maria occurred in 2024 and 2025, with most involving medications available at home. Erica Torres, the coordinator of the Paediatric Emergency Department, raised the alarm after the Orders of Pharmacists and Doctors highlighted the risks of the so-called “paracetamol challenge” promoted on social media, which encourages the deliberate intake of high doses of the drug. Torres noted that many overdoses involve various medications that young people have at home, and that they are aware of the lethal or toxic doses of paracetamol, possibly through social media content. She reported a case of a teenager who ingested 10 grams of paracetamol, which is a significant amount. The issue of voluntary medication overdoses has become a major concern for emergency services, with 232 cases recorded at Hospital Santa Maria in Lisbon over the past six years, more than half of which occurred in the last two years (131). The coordinator indicated that 60% of adolescents had a depressive or anxiety disorder, while about 30% had no pathology. Some adolescents under paediatric psychiatry care are overdosing on prescribed medications, but many also resort to paracetamol due to its easy availability. The 500-milligram tablet is sold over the counter, while the one-gram tablet requires a prescription. Although there are premeditated cases that constitute “true suicide attempts,” most cases are impulsive actions, often regretted later. The coordinator emphasized the need for greater vigilance from parents, recommending that medications be stored securely and that adults manage the medication of young people prescribed psychotropic drugs. She also called for increased attention in pharmacies when dispensing medications to minors and highlighted the role of families in supervising internet use and explaining risks. Torres believes the number of overdoses represents only “the tip of the iceberg” of a broader mental health issue, which is a serious concern. Panic attacks, anxiety, chest pain, and palpitations associated with psychological distress are common complaints in emergency services. Fátima Rato, coordinator of the INEM Poison Information Centre, stated that there have been no records of cases directly linked to the TikTok challenge, although intentional paracetamol overdoses in adolescents are noted. Rato warned that paracetamol overdoses can have serious consequences, including liver toxicity and, in extreme cases, the need for a transplant.